Synthesis and Antiinflammatory Activity of Alkenylphenylpropionic Acids
スポンサーリンク
概要
- 論文の詳細を見る
A series of 2-phenylpropionic acids substituted with a C_2-C_6 alkenyl group at the para position was synthesized by hydrolysis of the corresponding esters prepared by a new nickel-catalyzed coupling reaction of aryl Grignard reagents and 2-bromopropionic acid ester. Among the 2-(4-alkenylphenyl)propionic acids thus obtained, 2-[4-(2-metyl-1-propenyl)phenyl]propionic acid showed the most potent antiinflammatory activity in the carrageenin edema test, while 2-[4-(3-methyl-2-butenyl)phenyl]propionic acid showed almost the same activity and significantly lower toxicity in comparison with those of ibuprofen.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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天沼 二三雄
Research Center, Taisho Pharmaceutical Co., Ltd.
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曾田 馨
Research Center, Taisho Pharmaceutical Co., Ltd.
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樋口 昭平
大正製薬総合研究所
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畑山 勝男
Research Center, Taisho Pharmaceutical Co., Ltd.,
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畑山 勝男
Research Center Taisho Pharmaceutical Co. Ltd.
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樋口 昭平
Research Center Taisho Pharmaceutical Co. Ltd.
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樋口 昭平
大正製薬株式会社 開発研究所
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天沼 二三雄
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
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小川 利寿
Research Center, Taisho Pharmaceutical Co., Ltd.,
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天野 武宏
Research Center, Taisho Pharmaceutical Co., Ltd.,
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吉川 賢成
Research Center, Taisho Pharmaceutical Co., Ltd.,
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佐野 達彦
Research Center, Taisho Pharmaceutical Co., Ltd.,
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大内 裕
Research Center, Taisho Pharmaceutical Co., Ltd.,
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田名見 亨
Research Center, Taisho Pharmaceutical Co., Ltd.,
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太田 知己
Research Center, Taisho Pharmaceutical Co., Ltd.,
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小川 利寿
Research Center Taisho Pharmaceutical Co. Ltd.
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天沼 二三雄
Department Of Pharmacology Research Center Taisho Pharmaceutical Co. Ltd.
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天沼 二三雄
Research Center Taisho Pharmaceutical Co. Ltd.
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樋口 昭平
大正製薬(株)開発研究所
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大内 裕
Research Center Taisho Pharmaceutical Co. Ltd.
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天野 武宏
Research Center Taisho Pharmaceutical Co. Ltd.
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曾田 馨
Research Center Taisho Pharmaceutical Co. Ltd.
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田名見 亨
Research Center Taisho Pharmaceutical Co. Ltd.
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太田 知己
Research Center Taisho Pharmaceutical Co. Ltd.
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吉川 賢成
Research Center Taisho Pharmaceutical Co. Ltd.
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佐野 達彦
Research Center Taisho Pharmaceutical Co. Ltd.
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Hatayama K
Research Center Taisho Pharmaceutical Co. Ltd.
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