Pharmacological Studies of Furo[3,2-b]indole Derivatives. III. Correlation between Analgesic Effect and Effect on Central Nervous System of N-(3-Piperidinopropyl)-4-methyl-6-trifluoromethyl Furo[3,2-b]indole-2-carboxamide(FI-302) in Mice(Pharmacological)

概要

論文の詳細を見る
N-(3-Piperidinopropyl)-4-methyl-6-trifluoromethyl furo[3,2-b]indole-2-carboxamide(FI-302) is a new non-steroidal anti-inflammatory compound. The analgesic effect of FI-302 and its effect on the central nervous system(CNS) were compared with those of aspirin, chlorpromazine and chlordiazepoxide in mice subjected to various experimental conditions. FI-302 showed an analgesic effect with all the methods used, but aspirin, chlorpromazine and chlordiazepoxide showed analgesic effects only with the acetic acid-induced writhing method. Moreover, FI-302 inhibited spontaneous motor activity and fighting behavior induced by isolation and foot-shock, but had no effect on the hexobarbital-induced sleeping time. Aspirin had no effect on the CNS, but chlorpromazine and chlordiazepoxide showed inhibitory effects with all the methods used. Fighting behavior is related to emotional response, and pain is associated with emotional responses such as distress and anxiety. Thus, it is suggested that FI-302 is a new analgesic compound which has an inhibitory effect on the emotional response in the CNS.
公益社団法人日本薬学会の論文
1987-07-25