銅触媒とトリアルキルアミンによるsym-トリクロロベンゼンの部分アミノ化

概要

論文の詳細を見る
The partial amination of sym-trichlorobenzene with aqueous ammonia was studied under various conditions. In general, sym-trichlorobenzene has been aminated with ammonia to give 3, 5-diaminochlorobenzene by way of 3, 5- dichloroaniline in the presence of Cu catalyst. Authors have found that the addition of trialkylamines such as triethylamine or tripropylamine to the system increased the relative yield of 3, 5 - dichloroaniline to 86.9 % at 250°C. Similar behaviol of the added trialkylamines was recognized in the monoamination of dichlorobenzene isomers. The effects of the added trialkylamine in the monoamination are supposedly due to ; the poisoning of Cu catalyst and /or the protection of halogen group from the successive amination.
社団法人有機合成化学協会の論文