粉末薬剤の流動性に及ぼすアルミノケイ酸マグネシウムの影響

概要

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The flow properties of mixed powder of two components were investigated. Three kinds of magnesium aluminosilicate (MAS), which have different particle sizes, were preparated for use as an additive, and potato starch was used as a base particle. The fluidity was estimated by the measurement of the angle of repose. It was found that the optimal fluidity was obtained at some proportion of the additive, and this optimum proportion varies with particle size and moisture content of MAS. For example, optimum proportion was 0.75% by weight for MAS-I (7.72 μm in mean particle size) and 0.18% by weight for MAS-III (1.63 μm in mean particle size), A significant decrease was observed in optimum proportion for heat-treated MAS (200-400°, 1 hr) and steam-treated MAS (92% R.H.). The reason for the former seems to be adhesiveness due to activity of the performed dehydroxyl sites, and rehydration occurring on the surface of the base particle. In the latter, it seems that adsorbed water molecules on the surface of additives build bridges between MAS and base particle, and the contact between base particles is prevented by the additive particles.
公益社団法人日本薬学会の論文
1978-04-25