液相クロマトグラフィーを用いシアノ酢酸メチルを高収率に得る改良法

概要

論文の詳細を見る
Methods for the manufacture of cyanoaceticacid methyl ester via cyano-substitution of the chloroaceticacid methyl ester have been hitherto studied by many investigators, but good results have not yet been obtained. The authors have first made clear that the difficulties can be attributed to the impurities existing among the starting material and the product, and then have found a method which gives a good yield by removing these impurities before fractionating the product solution : the foreign compounds are eliminated by a column separation, of which carriers are basic and neutral alumina made in Woelm company. On the other hand, inspecting the structure and the physical properties of these aluminas, it was accounted for that their peculiarities depend not so much on their porous character as their solid base strength.
公益社団法人日本薬学会の論文
1969-04-25