気相におけるo-, m-, およびp-メチルアニソールの不均一系アンモ酸化

概要

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A search for catalysts effective for the ammoxidation of o-, m-, and p-methylanisole was undertaken. When a mixture of V_2O_5-ZrO_2 (wt ratio of 8 : 2) was used, o-methyl-anisole was converted to o-methoxybenzonitrile with a conversion of 48% and a selectivity of 55% (380°), m-methylanisole was converted to m-methoxybenzonitrile with a conversion of 49% and a selectivity of 41% (410°), and p-methylanisole was converted to p-methoxy-benzonitrile with a conversion of 64% and a selectivity of 51% (380°). A catalyst with a large V_2O_5 content showed an initially large catalytic activity which, however, deteriorated rapidly. High selectivity to methoxybenzonitrile was observed at small partial pressure of methylanisole. Catalytic activity was not very sensitive to the partial pressure of ammonia, but was very sensitive to the partial pressure of oxygen. For example, very rapid deterioration of catalytic activity was observed at small partial pressure, and considerable oxidation reaction was observed at a large partial pressure of oxygen. Time-and temperature dependence of the selectivity of the reaction products of ammoxidation of p-methylanisole were discussed.
公益社団法人日本薬学会の論文
1980-03-25