Syntheses of Dibenzo [b, g] azecines and Dibenzo [b, f] azonines
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概要
- 論文の詳細を見る
The benzyne reaction of 1-(2-bromo-4,5-dimethoxyphenethyl)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinoline (13) was examined by using sodium methylsulfinylmethanide and the dibenzo [b, g] azecine (16) was obtained. The 1-halogenophenethylisoquinoline (14) also yielded the corresponding dibenzo [b, g] azecine (17) under the similar conditions. The reductive deoxygenation of (16) and (17), followed by desulfurization of 14-(methylthio) methyl derivative (18) and (19) gave the corresponding 14-methyl derivative (20) and (21), respectively. The similar ring expansion occurred also in the case of 1-halogenobenzylisoquinoline (15) to give the dibenzo [b, f] azonine (29), which was converted to the 13-methyl derivative (31).
- 公益社団法人日本薬学会の論文
- 1975-09-25
著者
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渋谷 皓
Tokyo College of Pharmacy
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加納 慎蔵
Tokyo College of Pharmacy
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横松 力
Tokyo College of Pharmacy
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渋谷 皓
東京薬科大学 分子機能解析
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小川 利寿
Research Center, Taisho Pharmaceutical Co., Ltd.,
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横松 力
東京薬科大学 分子機能解析
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横松 力
東京薬科大学
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小川 利寿
Research Center Taisho Pharmaceutical Co. Ltd.
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高萩 洋子
Tokyo College of Pharmacy
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小見山 映二
Tokyo College of Pharmacy
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小川 利寿
Tokyo College of Pharmacy
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