最近のモルヒナン合成における新展開
スポンサーリンク
概要
- 論文の詳細を見る
Recent synthesis of morphinan and related compounds is reviewed. Synthetic methodologies are classified roughly into three categories, that is i) intramolecular arylation at the 4 <I>a</I>-position of 1-benzylisoquinolines, ii) formation of an ethanamine bridge between 4 <I>b</I>- and 9-position of phenanthrenes, iii) formation of a methylene bridge between 1 and 2-position of 4 <I>a</I>-arylisoquinolines. The former two methods are rather classic, but are improved as the more practical ways to get morphinans. The last one was found after 1980 and used for a synthesis of B/C-<I>trans</I>-morphinans. An asymmetiric synthesis of 1-substituted isoquinolines, key precursors for morphinans, was also described.
- 社団法人 有機合成化学協会の論文
著者
関連論文
- スフィンゴミエリナーゼ阻害剤の創製と細胞ストレスシグナル遮断剤としての応用
- 複素環上のο-Quinodimethane中間体を経由する6-Thiaellipticineおよび関連化合物の合成
- A Synthetic Application of Methylthioacetonitrile. I. A Synthesis of cis- and trans-β-Arylacrylonitriles, β, γ-Unsaturated Nitriles and Carbonyl Compounds
- ALUMINUM-MEDIATED ONE-POT CONVERSION OF α-AMINO ACID ESTERS TO THREO 2-AMINO ALCOHOLS WITH HIGH DIASTEREOSELECTIVITY
- A Highly Diastereoselective Synthesis of cis-4a-Aryloctahydro-cyclopenta[c]pyridine Derivatives through Tandem Radical Cyclization of α-Amino Radical-Polyene Species
- A Synthesis of Simple 4,4-Disubstituted Tetrahydroisoquinolines by Cyclization of α, α-Disubstituted Phenylacetamides
- 生物活性化合物の合成を指向するホスホン酸及びホスフィン酸誘導体の合成
- スフィンゴミエリナーゼ阻害剤によるインスリン抵抗性改善効果
- Highly Diastereoselective Synthesis of (3R, 4R)- and (3R, 4S)-β, γ-Diamino Acids from D-Phenylalanine
- Diastereoconversion of 1-Alkynyl-2-aminoalkanols through Oxazoline-2-ones with S_N2 Type Inversion of the Hydroxy Group
- The Stevens Rearrangement of Quarternary Isoquinolinium Salts
- α-フルオロホスホン酸合成の最近の進展
- α位にヘテロ原子団を有するホスホン酸誘導体合成の最近の進展
- 最近のモルヒナン合成における新展開
- Formation of Dibenzo [b, f] azecines by the Reaction of 1-Halogenophenethyl-1H-2-benzazepines with Dimsylsodium
- A Synthesis of Dibenz [b, f] azecines from 1-Halogenobenzyl-1H-2-benzazepines
- N-Demethylation of Dibenz [b, f] azonines with Mercuric Acetate
- Syntheses of Dibenzo [b, g] azecines and Dibenzo [b, f] azonines
- Synthesis of the Ochotensine Type 1-Spiroisoquinoline. Dimsylsodiuminduced Rearrangement of N-Methyltetrahydroprotoberberinium Salts
- Syntheses of 13a-Substituted Dibenzo [a, f] quinolizines
- Novel Syntheses of 5,6,12,12a-Tetrahydro-12a-methyldibenzo-[b, g] indolizine Systems
- 有機合成実験書
- 最近開発された新しい還元反応および試薬
- Intra- and Intermolecular Nucleophilic Cleavage of the Amide Bond of β-Lactams
- Syntheses of Dibenzo [b, f] azonines and Dibenzo [b, g] azecines through Ring Expansion of 1-Substituted Isoquinolines
- The C-N Fission of Dibenzo [b, g] indolizinium Salts with Dimsylsodium
- (+)-カリキュリンAついに全合成される
- 最近のモルヒナン合成における新展開
- 薬剤師国家試験から読み解く 6年制薬学教育 学びのツボ(第2回)国試出題問題〈物理・化学・生物〉からみる6年制薬学教育