Syntheses of Dibenzo [b, f] azonines and Dibenzo [b, g] azecines through Ring Expansion of 1-Substituted Isoquinolines
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概要
- 論文の詳細を見る
The reaction of 1-(2-bromo-4,5-methylenedioxyphenethyl)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinoline (13) with sodium methylsulfinylmethanide gave the dibenzo [b, g] azecine (14). The 1-benzyl analog possessing a methyl group at the 3-position was transformed to the 6,13-disubstituted dibenzo [b, f] azonine (33) under the similar conditions. 33 was converted to the corresponding 6,13-dimethyl derivative (35). Hydrogenolysis of the N-methyl-dibenzo [a, f] quinolizinium iodide (23) over Adams catalyst was also examined to give the dibenzo [b, g] azecine (24).
- 公益社団法人日本薬学会の論文
- 1976-04-25
著者
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渋谷 皓
Tokyo College of Pharmacy
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加納 慎蔵
Tokyo College of Pharmacy
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渋谷 皓
東京薬科大学
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高萩 洋子
Tokyo College of Pharmacy
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小見山 映二
Tokyo College of Pharmacy
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