Bisbenzylisoquinoline Alkaloids and Related Compounds. VI. A Modified Total Synthesis of the Stereoisomeric Mixture of Dauricine

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概要

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• The diamide (X) was prepared from 3,4-dimethoxyphenethylamine and acid chloride (IX). This compound (X) was also obtained by condensation of dimethyl 4-benzyloxy-3,4'-oxydiphenyldiacetate (VIIb) with the above amine. Cyclization of the diamide (X), followed by the reduction of the methiodide of XI, gave the stereoisomeric mixture of O-benzyldauricine (III), which was also obtained by Ullmann reaction of XIII with XIV.

• 社団法人日本薬学会の論文
• 1966-01-25

著者

• 亀谷 哲治

  Pharmaceutical Institute, Tohoku University School of Medicine

• 樹林 千尋

  東京薬科大学薬学部

• 高野 誠一

  Pharmaceutical Institute Tohoku University

• 加納 慎蔵

  Tokyo College of Pharmacy

• 桜井 邦好

  Tokyo College of Pharmacy

• 柳瀬 良文

  Pharmaceutical Institute, Tohoku University School of Medicine

• 樹林 千尋

  Pharmaceutical Institute, Tohoku University School of Medicine

• 飯田 英夫

  Tokyo College of Pharmacy

• 亀谷 哲治

  Pharmaceutical Institute Medical Faculty University Of Osaka

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