イソヒノリン誘導体及び関連化合物の合成研究(第37報)Heterocyclic Acid Amide又はOximeに対するAllylbenzeneの反応による1-置換3-メチル-3,4-ジヒドロイソヒノリン誘導体の一新製法
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概要
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Reactions of various heterocyclic aldoximes and acid amides with methyleugenol or safrole, by utilization of the new isoquinoline synthesis (Kametani procedure^<1〜5)>) gave the objective 1-substituted 3-methyl-6,7-dimethoxy (or 6,7-methylenedioxy)-3,4-dihydro-isoquinoline, but the yield was generally less than 30%. The acid amides used were furan-and thiophene-2-carboxylic amides, and 4-methylthiazole-5-carboxylic amide. As the oxime, 2-furfuraldoxime was used, but the use of pyridine-carboxylic amide did not give the objective and unexpectedly cyanopyridine was obtained.
- 公益社団法人日本薬学会の論文
- 1955-08-20
著者
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亀谷 哲治
Pharmaceutical Institute, Tohoku University School of Medicine
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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大槻 一夫
Pharmaceutical Institute, Medical Faculty, University of Osaka
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福井 巳芳
Pharmaceutical Institute, Medical Faculty, University of Osaka
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福井 巳芳
Pharmaceutical Institute Medical Faculty University Of Osaka
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大槻 一夫
Pharmaceutical Institute Medical Faculty University Of Osaka
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亀谷 哲治
Pharmaceutical Institute, Medical Faculty, University of Osaka
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