Novel Synthesis of Quinoline Derivatives with Triethyl Phosphite

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概要

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• Treatment of ethyl 4,5-dimethoxy-2-nitrobenzylidenemalonate (III), ethyl 4-benzyloxy-5-methoxy-2-nitrobenzylidenemalonate (IV), and ethyl 4,5-methylenedioxy-2-nitrobenzylidenemalonate (V) with triethyl phosphite at 160-170° for 20 hr afforded 2-ethoxy-3-ethoxycarbonyl-6,7-dimethoxyquinoline (VI), 7-benzyloxy-2-ethoxy-3-ethoxycarbonyl-6-methoxyquinoline (VII), and 2-ethoxy-3-ethoxycarbonyl-6,7-methylenedioxyquinoline (VIII), respectively, in 53-68% yield. On the other hand, the 6-benzyloxy-2-ethoxycarbonyl-5-methoxyindole (XIII) was obtained with the same treatment of ethyl 4-benzyloxy-3-methoxy-2-nitrocinnamate (XII).

• 社団法人日本薬学会の論文
• 1969-10-25

著者

• 八木 治彦

  Pharmaceutical Institute Tohoku University

• 亀谷 哲治

  Pharmaceutical Institute, Tohoku University School of Medicine

• 小笠原 国郎

  Pharmaceutical Institute Tohoku University

• 山中 徹

  東北大・薬

• 丹生 淳郷

  Pharmaceutical Institute, Tohoku University

• 山中 徹

  Pharmaceutical Institute, Tohoku University

• 亀谷 哲治

  Pharmaceutical Institute Medical Faculty University Of Osaka

• 丹生 淳郷

  日本ケミファ株式会社研究部

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