Studies on the Syntheses of Heterocyclic Compounds. LII. The Eschweiler-Clarke and Pictet-Spengler Reactions with β-Methoxysafrylamine.
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概要
- 論文の詳細を見る
The Eschweiler-Clarke and Pictet-Spengler reactions of β-methoxysafrylamine were examined. In the former reaction N, N-dimethyl-β-methoxysafrylamine was obtained in place of expected isoquinoline, but in the latter reaction four kinds of isoquinoline derivatives were formed according to reaction conditions of time and temperature. When heated for 30 minutes with formaldehyde solution, 3-methyl-1,2-dihydro-(IV) and 3-methyl-4-methoxy-1,2,3,4-tetrahydro-6,7-methylenedioxyisoquinoline (III) were obtained, while 2,3-dimethyl-1,2-dihydro-(VII) and 2,3-dimethyl-1,2,3,4-tetrahydro-6,7-methylene-dioxyisoquinoline (VI) were obtained when heated for 7 hours. Especially in the latter case, it is interesting that 4-methoxy derivative is obtained only by heating with formaldehyde solution although it could not be synthesized by the Bischler-Napieralski reaction and that, in addition, the substance (VII) was obtained very easily by way of (VI).
- 公益社団法人日本薬学会の論文
- 1959-07-20
著者
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亀谷 哲治
Pharmaceutical Institute, Tohoku University School of Medicine
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福本 圭一郎
東北大・薬
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福本 圭一郎
Pharmaceutical Institute, Tohoku University
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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加多木 豊之
Pharmaceutical Institute, Medical Faculty, University of Osaka
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福本 圭一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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加多木 豊之
School Of Pharmacy Osaka University
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