Studies on the Syntheses of Heterocyclic Compounds. CDLII. An Alternative Total Synthesis of Corydalactam

スポンサーリンク

概要

• 論文の詳細を見る

• Condenzation of 1-p-toluenesulfonylaziridine (V) with ethyl acetoacetate, followed by a ketalization of the resulting pyrrolidone (X), gave the ketal (XI), which was cleaved with sodium in liquid ammonia to give 3-acetyl-2-pyrrolidone ethylene ketal (II). Since this compound (II) had already been led to corydalactam (I), an alternative synthesis of corydalactam has been accomplished.

• 社団法人日本薬学会の論文
• 1971-11-25

著者

• 井原 正隆

  東北大院薬

• 亀谷 哲治

  Pharmaceutical Institute, Tohoku University School of Medicine

• 井原 正隆

  Pharmaceutical Institute, Tohoku University

• 井原 正隆

  東北大薬

• 井原 正隆

  東北大学薬学部

• 亀谷 哲治

  Pharmaceutical Institute Medical Faculty University Of Osaka

関連論文

• 95(P-24) 多成分反応による実用的シクロブタン合成法の開発と天然物合成への応用(ポスター発表の部)
• Studies on the Syntheses of Heterocyclic Compounds. CXCV. The Structure of a Yellow Substance formed by Mild Oxidation of Aminopyrine.
• Synthetic Studies on β-Lactam Antibiotics. XIV. Synthesis of 7H-Azeto [1,2-a] thieno [2,3-c] pyridine Derivatives
• 17 分子内Double Michael反応を利用するAtisineのエナンチオ選択的全合成(口頭発表の部)
• 10 触媒的環化アルケニル化反応を利用する生理活性天然物の合成研究(口頭発表の部)
• Studies on the Synthesis of Heterocyclic Compounds. DXIX. A Total Synthesis of (±)-Discretine by Thermolysis
• A Novel Synthesis of Isopavine Ring System
• Studies on the Syntheses of Heterocyclic Compounds. DX. A Novel Rearrangement of proerythrinadienol with Methyl Fluorosulfonate
• Studies on the Syntheses of Heterocyclic Compounds. CDXCIII. Reaction of N-Ethoxycarbonyl-5-methoxytryptamine with Methyl Fluorosulfonate ("Magic Methyl")
• Novel Synthesis of Quinoline Derivatives with Triethyl Phosphite
• The Oxidation of p-Toluidine with Potassium Ferricyanide in Liquid Ammonia
• Benzyne Reaction. II. Syntheses of Benzyl Cyanide Derivatives by Benzyne Reaction (Studies on the Syntheses of Heterocyclic Compounds. CCXLVII)
• Studies on the Syntheses of Heterocyclic Compounds. CCXLV. The Mass Spectra of Cryptaustoline Type Alkaloids
• Studies on the Syntheses of Heterocyclic Compounds. CCXXXVIII. A Modified Synthesis of Pummerer's Ketone
• An Improved Synthesis of Styphnic Acid
• Studies on the Syntheses of Tetracycline Derivatives. III. Synthetic Approach to Adriamycin-Synthesis of the Linear Tetracyclic Skeleton having the Same BC Ring System with Adriamycin
• An Alternative Synthesis of (±)-Dehydrogrisenfulvin by Enzymic Phenolic Oxidation by Homogenized Potato Peelings : Studies on the Syntheses of Heterocyclic Compounds. CCCLIII
• Electrolytic Oxidation. I. Phenolic Oxidation of p-Cresol by Electrolysis (Studies on the Syntheses of Heterocyclic Compounds. CCXXXVII
• Synthesis of Melanthioidine Derivative by Double Ullmann Reaction (Studies on the Syntheses of Heterocyclic Compounds. CCXXVI)
• Chichibabin Reaction. III. Chichibabin Reaction of 7-Methylquinoline and Migration of the Methyl Group in Friedel-Crafts Reaction of N-(m-Tolyl)- and N-(p-Tolyl)-β-chloropropionamide (Studies on the Syntheses of Heterocyclic Compounds. CCXV)
• Studies on the Syntheses of Heterocyclic Compounds. CCIX. Total Syntheses of (±)-Isococlaurine and (-)-Lotusine
• 17 神経保護作用物質セロフェンド酸の合成(口頭発表の部)
• The Nuclear Magnetic Resonance Spectra and Optical Rotatory Dispersion of Berbamunine, Magnoline and Two Diastereoisomers
• An Alternative Synthesis of Stereoisomeric Mixture of Magnoline by Ullmann Reaction (Studies on the Syntheses of Heterocyclic Compounds. CCXLVIII)
• Bisbenzylisoquinoline Alkaloids and Related Compounds. XI. Total Synthesis of Stereoisomeric Mixture of Magnoline
• Bisbenzylisoquinoline Alkaloids and Related Compounds. VI. A Modified Total Synthesis of the Stereoisomeric Mixture of Dauricine
• Capaurimine and Related Compounds. II. Syntheses of Position Isomers of Capaurimine and Capauridine : Studies on the Syntheses of Heterocyclic Compounds. CCCXIII
• An Alternative Synthesis of So-called Corpaverine (Studies on the Syntheses of Heterocyclic Compounds. CCXXXI)
• The Structure of Sendaverine and Its Total Synthesis
• 39 四員環の特性を活用したパラジウム錯体による新規分子内連続反応の開発と天然物合成への応用(口頭発表の部)
• 2 生合成類似の新規骨格転位反応を用いる(-)-アチシレン酸の全合成(口頭発表の部)
• 36 新規連続反応の開発と(±)-Cedranediolの合成(口頭発表の部)
• INDIRECT ELECTROREDUCTIVE CYCLIZATION FOR SYNTHESES OF KEY INTERMEDIATES OF SEVERAL INDOLE AND IPECAC ALKALOIDS
• P-6 分子内連続反応による小員環構築法の開発と数種のテルペン合成への利用(ポスター発表の部)
• 36 分子内連続反応による多環構造の新構築法の開発と天然物合成への利用(口頭発表の部)
• 17 セコロガニン由来アルカロイドのエチルマロン酸からの不斉合成(口頭発表の部)
• 47 アンドロスタン骨格の新規構築 : テストステロンの立体選択的合成(口頭発表の部)
• 45(PA1-3) 分子内Double Michael反応を用いるステロイド及びテルペンの全合成(ポスター発表の部)
• 44 Angular Triquinane型セスキテルペンの高立体選択的合成(±)-3-Oxosilphineneの全合成
• Diels-Alder反応様Double Michael反応およびその応用
• REACTION OF CONJUGATED ENONES WITH tert-BUTYLDIMETHYLSILYL TRIFLATE AND INTRAMOLECULAR ANNELATION
• 25 分子内Double Michael反応を用いるテルペン及びアルカロイドの合成
• STEREOSELECTIVE ALDOL REACTION OF A LITHIUM α-VINYL ENOLATE TO α-ALKOXY ALDEHYDES
• 48 分子内Double Michael反応の開発とそのAtisirene及びIsoatisirene合成への応用
• 5 分子内Diels-Alder反応をKey ReactionとするQuassinoidsの合成研究
• 動物性イソキノリンアルカロイド
• 41 一重項酸素酸化反応を利用した数種の天然有機化合物の合成
• Indolo[2,3-α]quinolizine誘導体の簡易合成法 : 複素環式化合物の合成研究 第835報
• チエナマイシンおよびその類縁体の合成 (「医薬品開発をめぐる生理活性物質の合成」特集号)
• Studies on the Syntheses of Heterocyclic Compounds. DCCLXVIII. Reaction of Pyrrolo [1,2-a] indole Derivatives with N-Bromosuccinimide in Protic Solvents
• Studies on the Syntheses of Heterocyclic Compounds. DCCLV. Iminoketene Cycloaddition. (4). Alternative Syntheses of 5,6,7,8-Tetrahydro-2,3-dimethoxy-8-oxoisoquinolo [1,2-b] quinazoline and Rutecarpine
• Studies on the Syntheses of Heterocyclic Compounds. DCCXXVIII. A Simple Synthesis of 1,3-Benzoxazin-4-ones from Salicylic Acid
• Studies on the Syntheses of Heterocyclic Compounds. DCXCII. A Novel Synthetic Route to Phthalideisoquinoline and Spirobenzylisoquinoline Type Alkaloids
• 41 数種のインドールアルカロイドの全合成
• Studies on the Syntheses of Heterocyclic Compounds. DCXXVI. A Modified Synthesis of Pentazocine
• Studies on the Syntheses of Heterocyclic Compounds. CDLXXXVII. Photolytic Synthesis and Rearrangement of Proerythrinadienones
• Biotransformation of (+)-Reticuline in Rat
• 降圧作用を有するProtoberberine誘導体の合成研究 : 複素環式化合物の合成研究第458報
• Studies on the Syntheses of Heterocyclic Compounds. CDLII. An Alternative Total Synthesis of Corydalactam
• 17 光化学反応によるイソキノリンアルカロイドの全合成
• 11 Capaurimineについて
• 7 GalanthamineおよびMorphineの全合成
• Coreximine関連化合物の合成研究(第2報) : Eschweiler-Clarke反応条件下における(±)-Coreximineの合成 : 複素環式化合物の合成研究 第163報
• Studies on the Syntheses of Heterocyclic Compounds. CCCXXI. Synthesis of Isoquinoline Derivatives having Twenty-four Membered Ring System by Ullmann Reaction
• Studies on the Syntheses of Heterocyclic Compounds. DCXLI A Convenient Synthesis of Hexadehydroyohimbine and a Total Synthesis of Yohimbine
• Studies on the Syntheses of Tetracycline Derivatives. I. Thermolytic Cycloaddition of o-Quinodimethanes with Naphthoquinone
• Studies on the Syntheses of Heterocyclic Compounds. DXVI. Total Syntheses of the Aporphine, Morphinandienone, and Tetrahydrodibenzopyrrocoline Alkaloids by Benzyne Reaction
• Total Syntheses of (±)-N-Nordasycarpidone and (±)-Dasycarpidone (Studies on the Syntheses of Heterocyclic Compounds. CDXVIII)
• Studies on the Syntheses of Heterocyclic Compounds. DXXV. Syntheses of Berberine and Related Compounds. III. Dealkylation of N-Substituted Protoberberinium Salts
• イソヒノリン誘導体及び関連化合物の合成研究(第37報)Heterocyclic Acid Amide又はOximeに対するAllylbenzeneの反応による1-置換3-メチル-3,4-ジヒドロイソヒノリン誘導体の一新製法
• イソヒノリン誘導体及び関連化合物の合成研究(第36報)2'-(p-アミノフェニル)ピリミジノイソヒノリン誘導体の脱アミノ化
• イソヒノリン誘導体及び関連化合物の合成研究(第35報)ピリミジノイソヒノリン類の二重結合転移及び赤外吸収スペクトルによる推定構造
• Studies on the Syntheses of Heterocyclic Compounds. DCCCXCII. An Efficient Stereoselective Synthesis of Potential Intermediates for Rauwolfia Alkaloids from Furan and Its Derivatives
• Studies on the Syntheses of Heterocyclic Compounds. CDXXXIV. The Abnormal Formation of 3-(4-Methoxyphenethyl)-6,7-methylenedioxy-1,2,3-benzotriazin-4-one in Case of Pschorr Reaction
• Aztequine and Related Compounds. IV. A Synthesis of 2,2'-Dihydroxy-4,4'-bis (7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolylmethyl) diphenyl Ether (Studies on the Syntheses of Heterocyclic Compounds. CCXXX)
• A Novel Dehydrazination Reaction. V. The Formation of Various Amides from Aliphatic and Aromatic Carboxylic Acid Hydrazides in the Presence of Chloral
• A Novel Dehydrazination Reaction
• Studies on the Syntheses of Heterocyclic Compounds. LXII. Synthesis of rac-Tetrahydrorotundine.
• Studies on the Syntheses of Heterocyclic Compounds. LIV. Formation of N-Alkyl-2-pyridone by Alkali Treatment of N-Alkyl-2-chloropyridinium Salt.
• Synthesis of rac-Tetrahydrorotundine
• Studies on the Syntheses of Heterocyclic Compounds. CDLVII. Synthesis of O-Benzylhomosalutaridine by Photolysis of Diazotized 1-(2-Aminophenethyl)-1,2,3,4-tetrahydroisoquinoline
• Modified Synthesis of Isosalutaridine (Studies on the Syntheses of Heterocyclic Compounds. CCCXXXVI)
• The Synthesis of C-nor-Androcymbine (Studies on the Syntheses of Heterocyclic Compounds. CCCXXIV)
• Formation of Morphinandienone-type Compound through Methylenedioxy Cleavage by Pschorr Cyclization
• Bisbenzylisoquinoline Alkaloids and Related Compounds. IX. A Modified Total Synthesis of Stereoisomeric Mixture of Magnolamine : Studies on the Syntheses of Heterocyclic Compounds. CXLV.
• Synthetic Approach to the Quassinoid Klaineanone : The Synthesis of a Potential Intermediate by Intramolecular Cycloaddition
• Synthesis of 1-Benzyloxindole Derivatives for the Study of Phenolic Oxidative Coupling (Studies on the Syntheses of Heterocyclic Compounds. CCCXLVII)
• Anti-cancer Agents. IV. : Desulfurization by Hydrazine Hydrate. (1). : The Reaction of o-, m-, and p-Nitrobenzyl Disulfide with Hydrazine Hydrate.
• Nitrenes. VIII. A Novel Synthesis of 3-Cyano-2-ethoxy-6,7-disubstitutedquinolines with Triethyl Phosphite (Studies on the Syntheses of Heterocyclic Compounds. CDXVI)
• 93(P-50) 橋頭位に窒素原子をもつ多環状天然物の簡易合成(ポスター発表の部)
• 41 植物生長制御物質GA_,GA_およびGA_の全合成(口頭発表の部)
• Magnolamine and Related Compounds. N. An Alternative Synthesis of D (-) and L (+)-N-Methylcoclaurine.
• 複数多機能性官能基による環構築法と天然物合成
• シダ植物の生殖器分化制御物質の構造と効率的合成
• 新規環構築法の開発とその生理活性天然物合成への利用
• ポリフィリン生合成における酵素と基質間の結合様式の解明
• 天然物合成をまとめた本
• チエナマイシンおよびその類縁体の合成
• Diels-Alder反応様Double Michael反応およびその応用
• 39 (-)および(+)-Petrosinの全合成(口頭発表の部)

もっと見る 閉じる

スポンサーリンク