Studies on the Syntheses of Heterocyclic Compounds. DCXCII. A Novel Synthetic Route to Phthalideisoquinoline and Spirobenzylisoquinoline Type Alkaloids

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概要

• 論文の詳細を見る

• Permanganate oxidation of 12-chloro-5,6,7,7a-tetrahydro-2,3,9,10-tetramethoxy-7-methylindeno [2,1-α] [3] benzazepine (5) in the presence of piperidine gave the diketospirobenzylisoquinoline (11) and the lactone (15), the latter of which was converted into erythro-and threo-phthalideisoquinoline (16 and 17). 2,3-Dihydro-7,8-dimethoxy-5-(2,3-dimethoxybenzoyl)-3-methyl-1H-3-benzazepine (4) was prepared from N-β-(3,4-dimethoxyphenethyl)-2,3-dimethoxyphenylacetamide (26) in four steps.

• 社団法人日本薬学会の論文
• 1977-02-25

著者

• 井原 正隆

  東北大院薬

• 亀谷 哲治

  Pharmaceutical Institute, Tohoku University School of Medicine

• 福本 圭一郎

  東北大・薬

• 福本 圭一郎

  Pharmaceutical Institute, Tohoku University

• 井原 正隆

  Pharmaceutical Institute, Tohoku University

• 井原 正隆

  東北大薬

• 井原 正隆

  東北大学薬学部

• 大沢 立志

  東北大薬

• 大沢 立志

  Pharmaceutical Institute, Tohoku University

• 平田 尚司

  Pharmaceutical Institute, Tohoku University

• PREMILA MANAKKALSIVARAMAN

  Pharmaceutical Institute, Tohoku University

• 亀谷 哲治

  Pharmaceutical Institute Medical Faculty University Of Osaka

• 福本 圭一郎

  Pharmaceutical Institute Tohoku University School Of Medicine

• 平田 尚司

  Pharmaceutical Institute Tohoku University

• Premila Manakkalsivaraman

  Pharmaceutical Institute Tohoku University

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