Studies on the Syntheses of Heterocyclic Compounds. DCCLV. Iminoketene Cycloaddition. (4). Alternative Syntheses of 5,6,7,8-Tetrahydro-2,3-dimethoxy-8-oxoisoquinolo [1,2-b] quinazoline and Rutecarpine
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概要
- 論文の詳細を見る
Treatment of the sulfinamide anhydride (2), prepared from anthranilic acid (1), with 3,4-dihydro-6,7-dimethoxyisocarbostyril (9) gave 5,6,7,8-tetrahydro-2,3-dimethoxy-8-oxoisoquinolo [1,2-b] quinazoline (10), which was also obtained by heating isatoic anhydride (3) with 9. Similarly, rutecarpine (6) was synthesised by the reactions of 1,2,3,4-tetrahydro-1-keto-β-carboline (13) with the sulfinamide anhydride (2) or isatoic anhydride (3). Heating 3,4-dihydro-β-carboline (5) with 3 also afforded rutecarpine (6). Furthermore the phosphates (8a) and (12) were isolated on treatment of the urethanes (7a) and (11) with phosphoryl chloride.
- 社団法人日本薬学会の論文
- 1978-06-25
著者
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井原 正隆
東北大院薬
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亀谷 哲治
Pharmaceutical Institute, Tohoku University School of Medicine
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福本 圭一郎
東北大・薬
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福本 圭一郎
Pharmaceutical Institute, Tohoku University
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井原 正隆
Pharmaceutical Institute, Tohoku University
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井原 正隆
東北大薬
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井原 正隆
東北大学薬学部
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大沢 立志
東北大薬
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大沢 立志
Pharmaceutical Institute, Tohoku University
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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福本 圭一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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