Coreximine関連化合物の合成研究(第2報) : Eschweiler-Clarke反応条件下における(±)-Coreximineの合成 : 複素環式化合物の合成研究第163報

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1-(3-Benzyloxy-4-methoxybenzyl)-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydroisoquinoline (VI) and 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline (VII) were synthesized according to the route shown in Chart 1. VI and VII were reacted with formic acid or acetic acid to obtain respectively (±)-O, O-dibenzylcoreximine (IX) and (±)-coreximine (VIII). At the same time, (±)-norcoralydine (X) was prepared from (±)-norlaudanosine (XII) under the same condition and X was identified with (±)-norcoralydine derived from (±)-coreximine. Norcoralydine was found to occur in dimorphic forms of granular crystals (Xa) of m.p. 145〜145.5° and prismatic crystals (Xb) of m.p. 155°.
社団法人日本薬学会の論文
1967-02-25