Indene関連化合物の研究(第5報) : 2-Nitro-1-indanone OximeのPolyphosphoric Acidによる環拡大反応について : 複素環式化合物の合成研究第173報

概要

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In an earlier work, it was found that the treatment of 2-nitro-1-tetralone oxime (II) with polyphosphoric acid resulted in the formation of 1-oxo-4,5-dihydro-1H-(1,2,4)-oxadiazolo-[4,3-a]quinoline (IV) and 4,5-dihydronaphtho[1,2-c]furazan 3-oxide (V). In the anticipation that the same treatment of 2-nitro-1-indanone oxime (I) might produce the similar compounds (VI and VII) corresponding to those of II, I was treated with 20 volumes of polyphospholic acid by warming at 45〜50° for 40〜50 minutes but the majority of the substance became resinous. The liquid obtained after removal of the resinous substance was salted out and extracted with ethyl acetate, affording two kinds of substances in 15% yield. These products were identified as 2-oximino-4-oxoisocarbostyril (VIII) and 2-oximino-1-indanone (IX).
公益社団法人日本薬学会の論文
1967-03-25