Studies on the Syntheses of Heterocyclic Compounds. DCCLIV. A Novel Method form Acetalisation of Formyl Group at the C_3-Position of 2,3-Dihydro-1H-pyrrolo [1,2-a] indole Skeleton
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概要
- 論文の詳細を見る
Reaction of 2,3-dihydro-7-methoxy-6-methyl-1H-pyrrolo [1,2-a] indole-9-carboxaldehydes (2), (3), (4), (5), and (6) with thiolacetic acid in the presence of 6 N sulphuric acid at room temperature gave 9-diacetylthiomethyl-2,3-dihydro-7-methoxy-6-methyl-1H-pyrrolo [1,2-a] indoles (12), (13), (14), (15), and (16), respectively. The same reaction of the compound (2) at 0° afforded 1-acetoxy-9-diacetylthiomethyl-2,3-dihydro-7-methoxy-6-methyl-8-nitro-1H-pyrrolo [1,2-a] indole (11). Successive treatment of the compound (11) with absolute methanol in the presence of sodium methoxide gave 2,3-dihydro-1-hydroxy-7-methoxy-9-dimethoxymethyl-6-methyl-8-nitro-1H-pyrrolo [1,2-a] indole (17).
- 公益社団法人日本薬学会の論文
- 1978-06-25
著者
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亀谷 哲治
Pharmaceutical Institute, Tohoku University School of Medicine
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福本 圭一郎
東北大・薬
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福本 圭一郎
Pharmaceutical Institute, Tohoku University
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高橋 喜美男
Pharmaceutical Institute, Tohoku University
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根本 英雄
Pharmaceutical Institute, Tohoku University School of Medicine
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根本 英雄
東北大薬
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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福本 圭一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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木川 良雄
Pharmaceutical Institute, Tohoku University
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木川 良雄
Pharmaceutical Institute Tohoku University
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高橋 喜美男
Pharmaceutical Institute Tohoku University
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