Bisbenzylisoquinoline Alkaloids and Related Compounds. VII. A Total Synthesis of the Stereoisomeric Mixture of Magnolamine
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概要
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The diamide (IX) was prepared from the 2,4'-oxy-4,5-bisbenzyloxydibenzoic acid (VII) and 3-methoxy-4-benzyloxyphenethylamine by Arndt-Eistert reaction. Cyclization of IX gave the dihydroisoquinoline (X); reduction of the dimethiodide (XI) with sodium borohydride, followed by hydrolysis with concentrated hydrochloric acid-ethanol (1 : 1), gave the stereoisomeric mixture of magnolamine (I).
- 公益社団法人日本薬学会の論文
- 1966-01-25
著者
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八木 治彦
Pharmaceutical Institute Tohoku University
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亀谷 哲治
Pharmaceutical Institute, Tohoku University School of Medicine
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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