Dimerization of Diphenolic Benzylisoquinolines by Phenolic Oxidative Coupling (Studies on the Syntheses of Heterocyclic Compounds. CXXVIII)

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概要

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• Ferric chloride oxidative coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(2-hydroxybenzyl)-6-methoxyisoquinoline (IIb) afforded two dimeric benzylisoquinolines, III in 1.6% yield and V in 1.1% yield, respectively. Eschweiler-Clarke reaction of III gave the corresponding N-methyl derivative (IV), which was identified with authentic sample. Ferricyanide oxidative coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(3-hydroxybenzyl)-6-methoxy-2-methylisoquinoline (IId) also gave the dimeric benzylisoquinoline (VI) in 0.4% yield, which was characterized by microanalysis and spectral data.

• 公益社団法人日本薬学会の論文
• 1969-10-25

著者

• 野口 功

  東北大学医学部薬学科

• 亀谷 哲治

  Pharmaceutical Institute Medical Faculty University Of Osaka

• 野口 功

  Pharmaceutical Institute, Tohoku University

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