Studies on the Syntheses of Heterocyclic Compounds. CDLXXXVIII. An Alternative Synthesis of"Isocularine"by an Intramolecular Ullmann Reaction
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概要
- 論文の詳細を見る
5,5a, 6,7,8-Pentahydro-1-hydroxy-2,11-dimethoxybenzo [b] oxepino [7,6,5-ij] isoquinoline (III) was synthesized by an intramolecular Ullmann reaction of 1-(3-benzyloxy-2-bromo-4-methoxybenzyl)-5-bromo-1,2,3,4-tetrahydro-8-hydroxy-7-methoxy-2-methylisoquinoline (X), followed by hydrogenolysis of the product (XI), and also by reduction of N-ethoxycarbonyl analogue (XV) derived from Ullmann reaction product (XIV) of the phenolic bromoisoquinoline (XIII).
- 公益社団法人日本薬学会の論文
- 1972-08-25
著者
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福本 圭一郎
東北大・薬
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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福本 圭一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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藤原 充雄
田辺製薬有機化学研究所
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藤原 充雄
Organic Chemistry Research Laboratory Of Tanabe Seiyaku Co. Ltd.
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