Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
スポンサーリンク
概要
- 論文の詳細を見る
The structure-activity relationship of acyl-His-trifluorinated leucinol derivatives as inhibitors of human renal renin is discussed based upon the tertiary structure of human renin, which was deduced from the crystal structure of penicillopepsin by assuming structural similarity. The structural requirements for the inhibitors and possible interactions at the renin binding site are discussed.
- 社団法人日本薬学会の論文
- 1988-09-25
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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田口 武夫
Tokyo College of Pharmacy
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赤羽 健司
キッセイ薬品工業株式会社中央研究所
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飯塚 欣二
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,
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上條 哲聖
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,
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赤羽 健司
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,
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梅山 秀明
School of Pharmaceutical Sciences, Kitasato University
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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上條 哲聖
キッセイ薬品工業株式会社中央研究所
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上条 哲聖
キッセイ薬品工業中央研究所
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梅山 秀明
School Of Pharmaceutical Sciences Kitasato University
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飯塚 欣二
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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小林 義郎
東京薬科大学薬学部
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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赤羽 健司
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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