Studies on Organic Fluorine Compounds. X. Reaction of Trifluoromethyl Group in Heterocycles with Sodium Amide
スポンサーリンク
概要
- 論文の詳細を見る
In the reactions of (trifluoromethyl) pyridines and (trifluoromethyl) benzopyridines with sodium amide, trifluoromethyl group, which has been considered to be very stable, was substituted with amino group and an unexpected reaction was observed. We propose mechanisms for these reactions.
- 公益社団法人日本薬学会の論文
- 1972-05-25
著者
-
小林 義郎
Tokyo College of Pharmacy
-
田口 茂
Tokyo College Of Pharmacy
-
熊懐 稜丸
Tokyo College of Pharmacy
-
榛沢 雄二
Tokyo College of Pharmacy
関連論文
- Quantitative Structure-in Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters
- Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
- Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
- Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
- Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
- Studies on Organic Fluorine Compounds. XLIII. The Ene Reaction of Hexafluoroacetone
- Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
- Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
- Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
- Studies on Organic Fluorine Compounds. II. Mass Spectrometry of Trifluoromethylated Pyridines.
- Syntheses of Ten-membered Ring Amine Derivatives and 1-Azabicyclo-[4,4,1] undecane from 3,4,6,7,8,9-Hexahydro-2H-quinolizine
- Studies on the Reaction of Heterocyclic Compounds. XV. N-Alkylation of 1,2,3,4-Tetrahydro-5-methyl-1,6-naphthyridine
- Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate
- STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE
- Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
- Studies on Organic Fluorine Compounds. VII. Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XLVI. Synthesis of 4-Trifluoromethyl-2 (5H)-furanone and 4-Trifluoromethyl-N-substituted Dihydropyrrol-2-ones
- Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran
- SYNTHESIS OF TRIFLUOROMETHYLATED LACTONE AND EPOXIDE
- TRIFLUOROMETHYLATION OF CHIRAL ALDEHYDE AND SYNTHESIS OF 6-DEOXY-6,6,6-TRIFLUOROHEXOSES
- Synthesis of Fluorinated Retinal : A C_6-C_7 s-trans Fixed Retinal Containing a Trifluoromethyl Group at the Terminal Position of the Conjugated System
- TRIFLUOROMETHYLATED ALLYLIC ANION AND RADICAL : GENERATION BY THE ELECTRONIC INVERSION OF II-ALLYLICPALLADIUM COMPLEX BY SAMARIUM DIIODIDE
- PALLADIUM(0)-CATALYZED REACTIONS OF TRIFLUOROMETHYLATED ALLYLIC ESTER DERIVATIVES : SYNTHESIS OF TRIFLUOROMETHYLATED CHRYSANTHEMIC ACID ESTER
- ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP(Communications to the Editor)
- SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
- KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
- Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
- Trifluoromethylation with Bromotrifluoromethane
- Studies on Organic Fluorine Compounds. XLIV. The Diels-Alder Reaction of Trifluoromethylated Cyclopropenyl Ketone and Its Imine
- Studies on the Organic Fluorine Compounds. XXIV. Photochemical Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XXI. Isomerization of Fluorinated Dewar Pyridine Derivative and Its Metal Complexes
- Studies on Organic Fluorine Compounds. XX. Synthesis and Reactions of a Substituted Dewar Pyridine
- 含フッ素芳香族化合物の原子価結合異性体-2-
- 含フッ素芳香族化合物の原子価結合異性体-1-
- Studies on Organic Fluorine Compounds. XIX. Synthesis and Reactions of"Dewar"Thiophene
- Studies on Organic Fluorine Compounds. XVI. : Stereochemistry in Fluorination of Sterols with Phenylfluorophosphoranes
- Studies on Organic Fluorine Compounds. XIII. Studies on Equilibrium of (Trifluoro- and/or Chlorodifluoromethyl)-dihydro-s-triazine Derivatives by ^F-Nuclear Magnetic Resonance Spectra
- Studies on Organic Fluorine Compounds. XII. Photolysis of (Fluoroalkyl)-s-triazines
- Studies on Organic Fluorine Compounds. XI. Reaction of Arylfluorophosphoranes with Alcohols
- Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes
- 複素5員環化合物の原子価結合異性体
- 有機化合物へのフッ素導入法
- 含フッ素生理活性物質の合成 (「医薬品開発をめぐる生理活性物質の合成」特集号)
- ペルフルオロアルキル芳香族の化学 (新しいフッ素化学)
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- CF3基を有するヘテロ環の化学 (ヘテロ環の化学)
- Studies on Organic Fluorine Compounds. XXII. Synthesis and Reactions of (Trifluoromethyl) benzofurans
- 有機フッ素化学とライフサイエンス
- Studies on Organic Fluorine Compounds. XVIII. On the Mechanism of the Conversion of Trifluoromethyl Group to Amino Group on a Quinoline Ring
- Studies on Organic Fluorine Compounds. XVII. Reaction of Benzotrifluoride Derivatives with Sodium Amide
- Studies on the Reactions of Heterocyclic Compounds. XIII. Basicity of 1,6-Naphthyridine and Its N-Oxides : Correlation to Peracid Oxidation
- Studies on the Reaction of Heterocyclic Compounds. XII. N-Oxidation of Diazabenzene and Diazanaphthalene
- Photolysis of 2-(Trifluoromethyl) quinoline 1-Oxides and 1-(Trifluoromethyl) isoquinoline 2-Oxide
- Synthese von Derivaten der Cinchona-Alkaloide. XXXIII. Synthese von 2'-Cyanoderivaten der Alkaloide der Chinin-Reihe
- Studies on the Reactions of Heterocyclic Compounds. X. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene
- Studies on the Reactions of Heterocyclic Compounds. IX. Syntheses of 1,10b-Dihydropyrrolo[2,1-α]isoquinolines and 2,3-Dihydropyrrolo[2,1-α]isoquinolines
- Studies on the Reactions of Heterocyclic Compounds. VI. 1,3-Dipolar Cycloaddition Reaction of Disubstituted Methylides of Isoquinoline and Pyridine with Acetylenic Compounds
- Studies on the Reactions of Heterocyclic Compounds. VIII. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Cyano (methoxycarbonyl)-methylide with Dimethyl Acetylenedicarboxylate : Structure and Reaction of the Adduct
- STEREOSELECTIVE SYNTHESIS OF gem-BISTRIFLUOROMETHYLCYCLOPROPANE DERIVATIVES
- Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)_2
- Studies on Organic Fluorine Compounds. IV. Conversion of Alcohols to Fluorides by Diphenyltrifluorophosphorane
- Studies on Organic Fluorine Compounds. III. Conversion of Alcohols to Fluorides by Difluorotriphenylphosphorane
- Studies on Organic Fluorine Compounds. LIV. : Synthesis of 2,2-Difluoroarachidonic Acid
- Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
- Studies on the Reactions of Heterocyclic Compounds. XI. Methylation of Heteroaromatic N-Oxides
- Oxidative Cyanation of Aromatic Amine Oxides
- Studies on the Reactions of Heterocyclic Compounds. III. Cyanation of 1,6-Naphthyridine N-Oxides
- Studies on the Reactions of Heterocyclic Compounds. I. Syntheses and Some Reactions of 1,6-Naphthyridine N-Oxides
- Studies on the Reactions of Heterocyclic Compounds. V. Syntheses of Diazinium Ylides and Their Conversion to Azaindolizines
- Studies on the Reactions of Heterocyclic Compounds. IV. Preparations and Reactions of Heterocyclic N-Ylides
- 7.規那塩基の変換
- 複素5員環化合物の原子価結合異性体
- 含フッ素生理活性物質の合成
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- Studies on Organic Fluorine Compounds. X. Reaction of Trifluoromethyl Group in Heterocycles with Sodium Amide
- 1-PHENYLSULFONYL-3,3,3-TRIFLUOROPROPENE I : THE MICHAEL-TYPE ADDITION REACTION
- Studies on the Reactions of Heterocyclic Compounds. II. Syntheses and Some Reactions of 1,6-Phenanthroline N-Oxides
- Studies on organic fluorine compounds.-1,2-
- Synthese von Derivaten der Cinchona-Alkaloide. XXX. Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin.
- Synthese von Derivaten der Cinchona-Alkaloide. XXIX. Uber Dihydroepinichin und seine Acylwanderung.
- Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin
- Synthese von Derivaten der Cinchona-Alkaloide. XXVIII. Synthese von 2'-Hydroxydihydronichin.
- Studies on the Organic Fluorine Compounds. IX. Reactions of (Trifluoromethyl) quinolines with Metal Hydrides
- Studies on Organic Fluorine Compounds. VIII. Alcoholysis of (Trifluoromethyl) quinolines
- Studies on Organic Fluorine Compounds. VI. Preparations and Reactions of (Trifluoromethyl) quinoline N-Oxides
- Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
- Studies on Organic Flourine Compounds. V. Preparations and Reactions of N-Oxides of Trifluoromethylated Pyridines
- SYNTHESES OF β, β-DIFLUOROCARBOXYLIC ACID DERIVATIVES THROUGH THE CLAISEN REARRANGEMENT OF 1,1-DIFLUORO-1-ALKEN-3-OLS