Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
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概要
- 論文の詳細を見る
Ring opening reactions of acetoxydifluorocyclopropanes with various nucleophiles were investigated. Alkaline hydrolysis of acetoxydifluorocyclopropane afforded the α, α-difluoro ketone, α-fluoro enone and, in the case of 4,α-fluoro-β-methoxy ketone (8), while reactions with CH_3Li, Grignard reagent and LiAlH_4 gave the corresponding fluoro allyl alcohol derivatives (15) exclusively, in good yields. The reaction of 3 with CH_3MgI in the presence of CuBr afforded 2-fluoro-3-methylcyclotridecanone (21).
- 公益社団法人日本薬学会の論文
- 1979-12-25
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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田口 武夫
Tokyo College of Pharmacy
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小林 義郎
東京薬科大学薬学部
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清水 弘子
Tokyo College Of Pharmacy
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真々田 みどり
Tokyo College Of Pharmacy
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室橋 肇
Tokyo College of Pharmacy
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