Studies on the Reactions of Heterocyclic Compounds. V. Syntheses of Diazinium Ylides and Their Conversion to Azaindolizines
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概要
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Four types of azaindolizines, pyrrolo [1,2-b] pyridazines (XVIa, b), pyrrolo [1,2-a]-pyrimidine (XVII), pyrrolo [1,2-a] pyrazines (XIXa, b) and pyrazolo [1,5-b] pyridazines (XXIa, b) were synthesized by the 1,3-dipolar cycloaddition of diazinium dicyanomethy-lides (IVa, b V and VIa, b) and pyridazine N-imines (VII and VIII) with dimethyl acetylenedicarboxylate. Imidazo [1,2-b] pyridazine (XXII) was synthesized by the intramolecular cyclization of VII and VIII with sodium methoxide. Further, an improved method for VII and VIII by N-amination of pyridazines with hydroxylamine O-sulfonic acid was devised. The nuclear magnetic resonance, ultraviolet and infrared spectra of the ylides and azaindolizines mentioned above were also discussed.
- 公益社団法人日本薬学会の論文
- 1971-10-25
著者
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小林 義郎
Tokyo College of Pharmacy
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久津間 輝雄
Tokyo College Of Pharmacy:(present Address) Research Laboratories Ohta Seiyaku Co. Ltd.
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久津間 輝雄
(Present Address)Research Laborartoies, Ohta Seiyaku Co., Ltd.
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森永 邦夫
(Present address)Shizuoka College of Pharmacy
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