Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
Fluorine-modified acetyl glyceryl ether phosphorylcholines (platelet activating factors; PAFs) were efficiently synthesized in an enantioselective manner by the coupling of a D-threitol.derivative with fluorinated long-chain alkoxy methanesulfonates. The introduction of a trifluoromethyl group at the terminal of the alkyl ether chain decreased the hypotensive activity and platelet activation considerably. As the number of fluorine atoms in the alkyl ether chain was increased, both activities were gradually restored, but no selective agonist was obtained from among the fluorinated PAFs.
- 社団法人日本薬学会の論文
- 1987-02-25
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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小林 進
(present Address)sagami Chemical Research Center
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田口 武夫
Tokyo College of Pharmacy
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小林 義郎
東京薬科大学薬学部
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工藤 一郎
Faculty of Pharmaceutical Sciences, The University of Tokyo
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井上 圭三
Faculty of Pharmaceutical Sciences, The University of Tokyo
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大野 雅二
(Present address)Eisai Co., Ltd.
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小林 進
Faculty of Pharmaceutical Science, University of Tokyo
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藤田 かがり
Faculty of Pharmaceutical Sciences, University of Tokyo
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野島 庄七
Faculty of Pharmaceutical Sciences, University of Tokyo
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小田切 誠
Tokyo College of Pharmacy
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大野 雅二
(present Address)eisai Co. Ltd.
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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野島 庄七
帝京大・薬
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野島 庄七
Faculty Of Pharmaceutical Sciences University Of Tokyo
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藤田 かがり
Faculty Of Pharmaceutical Sciences University Of Tokyo
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