Studies on Organic Fluorine Compounds. XVIII. On the Mechanism of the Conversion of Trifluoromethyl Group to Amino Group on a Quinoline Ring
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概要
- 論文の詳細を見る
The mechanism for a novel reaction of a trifluoromethyl group as a leaving group is confirmed. Reaction of 2-(heptafluoro-n-propyl) quinoline with sodium amide gave 2-aminoquinoline, which shows that a perfluoroalkyl group could behave as a leaving group in some SNAr reactions. Tris (trifluoromethyl)-s-triazine gave a 1,4-ammonia adduct, which shows that the reaction passed through addition-elimination mechanism.
- 公益社団法人日本薬学会の論文
- 1975-09-25
著者
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小林 義郎
Tokyo College of Pharmacy
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熊懐 稜丸
Tokyo College of Pharmacy
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榛沢 雄二
Tokyo College of Pharmacy
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三村 雅隆
Tokyo College of Pharmacy
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