KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
スポンサーリンク
概要
- 論文の詳細を見る
Racemic fluoroalkyl (E)-vinyl carbinols (1a-d) were kinetically resolved by Sharpless epoxidatlon. The optical purity of the resolved alcohols was excellent (98% ee) in mono- and difluoromethyl derivatives (1b and 1c) and moderate (60% ee) in a trifluoromethyl compound (1a).
- 公益社団法人日本薬学会の論文
- 1987-04-25
著者
-
小林 義郎
Tokyo College of Pharmacy
-
小林 義郎
東京薬科大学薬学部
-
川越 敬一
Tokyo College Of Pharmacy
-
榛澤 雄二
Tokyo College of Pharmacy
-
伊藤 雅之
Tokyo College of Pharmacy
-
榛澤 雄二
東京薬科大学薬学部
関連論文
- Quantitative Structure-in Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters
- Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
- 当代留学事情
- Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
- Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
- PREPARATION OF (22S)- AND (22r)-24-HOMO-26,26,26,27,27,27-HEXAFLUORO-1,22,25-TRIHYDROXY-24-YNE-VITAMIN D_3
- Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
- Studies on Organic Fluorine Compounds. XLIII. The Ene Reaction of Hexafluoroacetone
- Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
- Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
- Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
- 微量分析30年 : 池川信夫先生にきく
- 大腸がんとビタミンD : 含フッ素1,25-(OH)_2D_3アナログDD-003のin vivo実験
- Studies on Organic Fluorine Compounds. II. Mass Spectrometry of Trifluoromethylated Pyridines.
- Syntheses of Ten-membered Ring Amine Derivatives and 1-Azabicyclo-[4,4,1] undecane from 3,4,6,7,8,9-Hexahydro-2H-quinolizine
- Studies on the Reaction of Heterocyclic Compounds. XV. N-Alkylation of 1,2,3,4-Tetrahydro-5-methyl-1,6-naphthyridine
- Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate
- STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE
- Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
- Studies on Organic Fluorine Compounds. VII. Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XLVI. Synthesis of 4-Trifluoromethyl-2 (5H)-furanone and 4-Trifluoromethyl-N-substituted Dihydropyrrol-2-ones
- Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran
- SYNTHESIS OF TRIFLUOROMETHYLATED LACTONE AND EPOXIDE
- 有機フッ素化合物の合成と反応 : 30年の研究を振り返って
- Preparation and Biological Activity of 24-Epi-26,26,26,27,27,27-hexafluoro-1α, 25-dihydroxyvitamin D_2
- TRIFLUOROMETHYLATION OF CHIRAL ALDEHYDE AND SYNTHESIS OF 6-DEOXY-6,6,6-TRIFLUOROHEXOSES
- Synthesis of Fluorinated Retinal : A C_6-C_7 s-trans Fixed Retinal Containing a Trifluoromethyl Group at the Terminal Position of the Conjugated System
- TRIFLUOROMETHYLATED ALLYLIC ANION AND RADICAL : GENERATION BY THE ELECTRONIC INVERSION OF II-ALLYLICPALLADIUM COMPLEX BY SAMARIUM DIIODIDE
- オクテット
- PALLADIUM(0)-CATALYZED REACTIONS OF TRIFLUOROMETHYLATED ALLYLIC ESTER DERIVATIVES : SYNTHESIS OF TRIFLUOROMETHYLATED CHRYSANTHEMIC ACID ESTER
- ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP(Communications to the Editor)
- SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
- KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
- Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
- Trifluoromethylation with Bromotrifluoromethane
- Studies on Organic Fluorine Compounds. XLIV. The Diels-Alder Reaction of Trifluoromethylated Cyclopropenyl Ketone and Its Imine
- フッ素薬学のこれから
- アシルジルコノセン錯体を求核的アシル基供与体とする炭素-炭素結合形成反応
- Studies on the Organic Fluorine Compounds. XXIV. Photochemical Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XXI. Isomerization of Fluorinated Dewar Pyridine Derivative and Its Metal Complexes
- Studies on Organic Fluorine Compounds. XX. Synthesis and Reactions of a Substituted Dewar Pyridine
- Studies on Organic Fluorine Compounds. XIX. Synthesis and Reactions of"Dewar"Thiophene
- Studies on Organic Fluorine Compounds. XVI. : Stereochemistry in Fluorination of Sterols with Phenylfluorophosphoranes
- Studies on Organic Fluorine Compounds. XIII. Studies on Equilibrium of (Trifluoro- and/or Chlorodifluoromethyl)-dihydro-s-triazine Derivatives by ^F-Nuclear Magnetic Resonance Spectra
- Studies on Organic Fluorine Compounds. XII. Photolysis of (Fluoroalkyl)-s-triazines
- Studies on Organic Fluorine Compounds. XI. Reaction of Arylfluorophosphoranes with Alcohols
- Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes
- 有機化合物へのフッ素導入法
- ペルフルオロアルキル芳香族の化学 (新しいフッ素化学)
- CF3基を有するヘテロ環の化学 (ヘテロ環の化学)
- Studies on Organic Fluorine Compounds. XXII. Synthesis and Reactions of (Trifluoromethyl) benzofurans
- Studies on Organic Fluorine Compounds. XVIII. On the Mechanism of the Conversion of Trifluoromethyl Group to Amino Group on a Quinoline Ring
- Studies on Organic Fluorine Compounds. XVII. Reaction of Benzotrifluoride Derivatives with Sodium Amide
- Studies on the Reactions of Heterocyclic Compounds. XIII. Basicity of 1,6-Naphthyridine and Its N-Oxides : Correlation to Peracid Oxidation
- Studies on the Reaction of Heterocyclic Compounds. XII. N-Oxidation of Diazabenzene and Diazanaphthalene
- Photolysis of 2-(Trifluoromethyl) quinoline 1-Oxides and 1-(Trifluoromethyl) isoquinoline 2-Oxide
- Synthese von Derivaten der Cinchona-Alkaloide. XXXIII. Synthese von 2'-Cyanoderivaten der Alkaloide der Chinin-Reihe
- Studies on the Reactions of Heterocyclic Compounds. X. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene
- Studies on the Reactions of Heterocyclic Compounds. IX. Syntheses of 1,10b-Dihydropyrrolo[2,1-α]isoquinolines and 2,3-Dihydropyrrolo[2,1-α]isoquinolines
- Studies on the Reactions of Heterocyclic Compounds. VI. 1,3-Dipolar Cycloaddition Reaction of Disubstituted Methylides of Isoquinoline and Pyridine with Acetylenic Compounds
- Studies on the Reactions of Heterocyclic Compounds. VIII. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Cyano (methoxycarbonyl)-methylide with Dimethyl Acetylenedicarboxylate : Structure and Reaction of the Adduct
- STEREOSELECTIVE SYNTHESIS OF gem-BISTRIFLUOROMETHYLCYCLOPROPANE DERIVATIVES
- Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)_2
- Studies on Organic Fluorine Compounds. IV. Conversion of Alcohols to Fluorides by Diphenyltrifluorophosphorane
- Studies on Organic Fluorine Compounds. III. Conversion of Alcohols to Fluorides by Difluorotriphenylphosphorane
- Studies on Organic Fluorine Compounds. LIV. : Synthesis of 2,2-Difluoroarachidonic Acid
- Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols
- Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
- Studies on the Reactions of Heterocyclic Compounds. XI. Methylation of Heteroaromatic N-Oxides
- Oxidative Cyanation of Aromatic Amine Oxides
- Studies on the Reactions of Heterocyclic Compounds. III. Cyanation of 1,6-Naphthyridine N-Oxides
- Studies on the Reactions of Heterocyclic Compounds. I. Syntheses and Some Reactions of 1,6-Naphthyridine N-Oxides
- 実用的な有機合成反応
- Studies on the Reactions of Heterocyclic Compounds. V. Syntheses of Diazinium Ylides and Their Conversion to Azaindolizines
- Studies on the Reactions of Heterocyclic Compounds. IV. Preparations and Reactions of Heterocyclic N-Ylides
- 7.規那塩基の変換
- 複素5員環化合物の原子価結合異性体
- 含フッ素生理活性物質の合成
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- ジルコノセン錯体を用いた炭素一炭素結合形成反応の新展開
- Studies on Organic Fluorine Compounds. X. Reaction of Trifluoromethyl Group in Heterocycles with Sodium Amide
- 1-PHENYLSULFONYL-3,3,3-TRIFLUOROPROPENE I : THE MICHAEL-TYPE ADDITION REACTION
- ビタミンD3のフッ素による化学修飾
- Studies on the Reactions of Heterocyclic Compounds. II. Syntheses and Some Reactions of 1,6-Phenanthroline N-Oxides
- オクテット
- 有機フッ素化合物の合成と反応
- 有功会員 溝口歌子先生を悼む
- 名誉会員R.B.Woodward教授を悼む
- Studies on organic fluorine compounds.-1,2-
- Synthese von Derivaten der Cinchona-Alkaloide. XXX. Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin.
- Synthese von Derivaten der Cinchona-Alkaloide. XXIX. Uber Dihydroepinichin und seine Acylwanderung.
- Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin
- Synthese von Derivaten der Cinchona-Alkaloide. XXVIII. Synthese von 2'-Hydroxydihydronichin.
- Studies on the Organic Fluorine Compounds. IX. Reactions of (Trifluoromethyl) quinolines with Metal Hydrides
- Studies on Organic Fluorine Compounds. VIII. Alcoholysis of (Trifluoromethyl) quinolines
- Studies on Organic Fluorine Compounds. VI. Preparations and Reactions of (Trifluoromethyl) quinoline N-Oxides
- Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
- Studies on Organic Flourine Compounds. V. Preparations and Reactions of N-Oxides of Trifluoromethylated Pyridines
- SYNTHESES OF β, β-DIFLUOROCARBOXYLIC ACID DERIVATIVES THROUGH THE CLAISEN REARRANGEMENT OF 1,1-DIFLUORO-1-ALKEN-3-OLS