Studies on the Reactions of Heterocyclic Compounds. IX. Syntheses of 1,10b-Dihydropyrrolo[2,1-α]isoquinolines and 2,3-Dihydropyrrolo[2,1-α]isoquinolines
スポンサーリンク
概要
- 論文の詳細を見る
2-(Methoxycarbonylmethyl)- (I), 2-cyanomethyl- (VIII), and 2-phenacyl-isoquinoli nium bromide (XII) react with dimethyl acetylenedicarboxylate, in the presence of tri-ethylamine, and form the corresponding 1,10b-dihydropyrrolo[2,1-a]isoquinoline (IV, X, and XIV) and aromatized compounds (V, XI, and XV). Treatment of IV, X, and XIV with hydrogen chloride in benzene, with subsequent neutralization with potassium carbonate, results in isomerization to stable 2,3-trans-2,3-dihydropyrrolo[2,1-a]isoquinolines (VII, XX, and XXI).
- 公益社団法人日本薬学会の論文
- 1972-12-25
著者
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小林 義郎
Tokyo College of Pharmacy
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藤山 和男
Faculty Of Pharmaceutical Sciences Osaka University
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関根 安男
Research Foundation Itsuu Laboratory
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久津間 輝雄
Tokyo College of Pharmacy
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関根 安男
Tokyo College of Pharmacy
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藤山 和男
Tokyo College of Pharmacy
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久津間 輝雄
Tokyo College Of Pharmacy:(present Address) Research Laboratories Ohta Seiyaku Co. Ltd.
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