Novel Synthesis of Three Types of C-Terminal Components of Renin Inhibitors from Unnatural(2S, 3S)-Tartaric Acid

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概要

• 論文の詳細を見る

• The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural(2S, 3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could explain the stereochemical outcome of the addition reaction. The addition product could be elaborated into three types of C-terminal components of renin inhibitors by employing oxidative cleavage of the 1,2-diol moiety, epoxide formation with inversion of configuration, and epoxide opening with a nucleophile.

• 社団法人日本薬学会の論文
• 1991-10-25

著者

• 竹本 佳司

  Faculty Of Pharmaceutical Sciences Osaka University

• 原田 弘

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 上條 哲聖

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• 上條 哲聖

  キッセイ薬品工業株式会社中央研究所

• 上条 哲聖

  キッセイ薬品工業中央研究所

• 原田 弘

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• 松本 光代

  Sagami Chemical Research Center

• 寺島 孜郎

  相模中研

• 中谷 和彦

  相模中研:(現)大阪市立大学理学部

• Takemoto Yoshiji

  Faculty Of Pharmaceutical Sciences Osaka University

• Takemoto Y

  Graduate School Of Pharmaceutical Sciences Kyoto University

• 寺島 孜郎

  Sagami Chemical Research Center

• 小林 祐子

  Sagami Chemical Research Center

• 竹本 佳司

  Sagami Chemical Research Center

• 中谷 和彦

  Sagami Chemical Research Center

• 伊藤 芳雄

  Sagami Chemical Research Center

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