Novel Ethynylcerium(III) Reagents as Efficient Tools for Constructing the α-Hydroxy Methyl Ketone Moiety of Anthracyclinones
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概要
- 論文の詳細を見る
The title cerium(III) reagents (7-10) were found to react with 5,8-dimethoxy-2-tetralone (11a) and 5,12-dihydroxy-1,2,3,4-tetrahydronaphthacene-2,6,11-trione (15) more efficiently than the corresponding lithium and magnesium reagents (3,5,and 4,6), giving the addition products (12a, 13a, and 17) in high yields. Hydration of these adducts readily afforded the α-hydroxy methyl ketones, 2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol (14a), and 2-acetyl-2,5,12-trihydroxy-1,2,3,4-tetrahydronaphthacene-6,11-dione (4-demethoxy-7-deoxydaunomycinone) (18), which are versatile synthetic intermediates for optically active 4-demethoxyanthracyclinones.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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寺島 孜郎
Sagami Chemical Research Center
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寺島 孜郎
(財)相模中央化学研究所
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木村 芳一
相模中研
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寺島 孜郎
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)sagami Chemical Research Cen
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鈴木 三千代
Sagami Chemical Research Center
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木村 芳一
Sagami Chemical Research Center
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