立体化学の研究(第55報)不斉エポキシ化触媒としてのモリブデン錯体の合成

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概要

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• Because of the increasing importance of optically active epoxides in biological and pharmaceutical chemistry as well as in organic syntheses, the asymmetric epoxidation reaction was selected from less-developed asymmetric oxidation reactions, and the possible exploitation of the asymmetric epoxidation catalysts was investigated. Two types of the chiral molybdenum (VI) catalysts (1 and 2) involving optically active N-alkyl-β-aminoalcohols (9 and 10) as stable chiral ligands and acetylacetone as a replaceable bidentate ligand, were designed, based on the proposed mechanism for the epoxidation of allylic alcohols with alkyl hydroperoxides which could be catalyzed by metal complexes. Although attempted preparations of the former metal complexes (1) were unsuccessfull, the latter molybdenum (VI) complexes (2b-d) were successfully synthe-sized by the ligand exchange reaction of molybdenum dioxyacetylacetonate [MoO_2 (acac)_2] (3) with (1R, 2S)-N-alkylephedrines (10b-d).

• 社団法人日本薬学会の論文
• 1980-03-25

著者

• 山田 俊一

  東京大学

• 山田 俊一

  東京大学薬学部

• 寺島 孜郎

  (財)相模中央化学研究所

• 益子 敏夫

  東京大学薬学部

• 寺島 孜郎

  東京大学薬学部

• 寺島 孜郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)sagami Chemical Research Cen

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