Amino Acids and Peptides. XXXI. Phosphorus in Organic Synthesis. XVIII. Synthesis of Porcine Motilin by the Solid-phase Method using Diphenyl Phosphorazidate (DPPA) and Diethyl Phosphorocyanidate (DEPC)

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概要

• 論文の詳細を見る

• Synthesis of porcine motilin, which exhibits a gastric motor stimulating activity, was accomplished by the solid-phase method with diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC) as coupling reagents. The purified synthetic peptide showed characteristic contractile activity towards the duodenum, colon and jejunum in the rabbit. Its potency was almost the same as that of the natural material.

• 社団法人日本薬学会の論文
• 1980-11-25

著者

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  東京大学

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 伊古田 暢夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 塩入 孝之

  (Present address)Faculty of Pharmaceutical Sciences, Nagoya City University

• 山田 俊一

  (Present address)Faculty of Pharmaceutical Sciences, Josai University

• 橘 真郎

  Research Laboratories, Eisai Co., Ltd.

• 橘 真郎

  エーザイ

• 橘 真郎

  Research Laboratories Eisai Co. Ltd.

• 伊古田 暢夫

  National Institute Of Radiological Sciences

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