New Methods and Reagents in Organic Synthesis. 26. Reductive Desulfonylation of α-Sulfonylacetates

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概要

• 論文の詳細を見る

• α-Acyl-α-benzylsulfonyldiazomethanes (2a-d) have been converted to α-benzylsulfonyl-α-substituted-acetic acids (7a-d) by means of the Wolff rearrangement. Reductive removal of the benzylsulfonyl group of 7b-d can be achieved by the use of sodiumethanol in tetrahydrofuran. α-Benzylsulfonyl-α-substituted-propionic acids (9a-d), prepared from benzyl α-benzylsulfonyl-α-substituted-acetates (3a-d), were also debenzyl-sulfonylated under similar reductive conditions. The overall process, in combination with the Arndt-Eistert synthesis of α-sulfonylacetates from acyl chlorides and benzylsulfonyl-diazomethane (1), provides a new, safe method for the homologation of carboxylic acids.

• 公益社団法人日本薬学会の論文
• 1982-08-25

著者

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 塩入 孝之

  名城大学薬学部

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 青山 豊彦

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 青山 豊彦

  名古屋市立大学大学院薬学研究科

• 郭 英徹

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 青山 豊彦

  Faculty Of Pharmaceutical Sciences Nagoya City University

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