A Resin-promoted Williamson's Alkyl Aryl Ether Synthesis. Methylation of 2-tert-Butyl-5-methylphenol with Methyl Chloride
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概要
- 論文の詳細を見る
The use of easily recoverable tri-n-butylphosphoniummethylated polystyrene resin (phosphonium resin catalyst) under triphasic reaction conditions was proposed in Williamson's alkyl aryl ether synthesis. O-Methylation of 2-tert-butyl-5-methylphenol with methyl chloride was easily carried out in the presence of the phosphonium resin catalyst under basic conditions to give 2-tert-butyl-5-methylphenyl methyl ether in excellent yield. A few other phenols were also O-alkylated under similar triphasic reaction conditions to give alkyl aryl ethers.
- 1981-08-25
著者
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浜田 康正
Faculty of Pharmaceutical Sciences, Nagoya City University
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塩入 孝之
Faculty of Pharmaceutical Sciences, Nagoya City University
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加藤 信治
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
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塩入 孝之
Faculty Of Pharmaceutical Sciences Nagoya City University
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塩入 孝之
名古屋市大・薬
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加藤 信治
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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加藤 信治
Faculty of Pharmaceutical Sciences, Nagoya City University
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各務 裕子
Faculty of Pharmaceutical Sciences, Nagoya City University
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各務 裕子
Faculty Of Pharmaceutical Sciences Nagoya City University
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