15 Evans-Aldol反応を鍵工程とするドラスタチン10の立体選択的全合成(口頭発表の部)

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概要

• 論文の詳細を見る

• Dolastatin 10, a potent antineoplastic substance, was isolated from an Indian Ocean sea hare, Dolabella auricularia. The absolute stereostructure of dolastatin 10, four constituents of which are unusual amino acids, was unambiguously determined by its total synthesis to be 1. Since the reported synthesis lacks stereo-selectivity, we have developed a more efficient route to dolastatin 10, a medicinally interesting peptide. Z-(S)-Dolaphenine was prepared by the Hantzsch method using Z-L-Phe-NH_2 as a starting material. (2R, 3R, 4S)-Dolaproine was prepared from Boc-(S)-prolinal (5) and N-propionyloxazolidinone 4 by the Evans aldol methodology. The unexpected threo aldol adduct 7 was produced as the major product with a small amount of the expected erythro adduct 6 when di-n-butylboron triflate was used in excess (Table 1). Stereochemistries of these aldol adducts were determined on the basis of ^1H-NMR analyses of their corresponding cyclic derivatives 18. Further investigation about this reversal of selectivity was carried out with a variety of aldehydes including amino aldehydes under the above reaction conditions (Table 2). (3R, 4S, 5S)-Dolaisoleuine, an isostatine analogue, was prepared from Boc-L-isoleucine via the β-ketoester 22, and (S)-dolavaline was prepared from L-valine according to the literature. Assembling each constituent obtained above was efficiently carried out in a stepwise manner from the C-terminal. DEPC was mainly used for the coupling, and the attachment of Boc-L-valine with the tripeptide fragment was accomplished by use of Bop-Cl. Dolastatin 10 (1) thus synthesized was identical with the natural one in every respect.

• 天然有機化合物討論会の論文
• 1991-09-07

著者

• 濱田 康正

  名市大・薬

• 塩入 孝之

  名市大・薬

• 塩入 孝之

  名城大院・総合学術

• 塩入 孝之

  名古屋市大・薬

• 濱田 康正

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 林 恭子

  名市大・薬

• 濱田 康正

  Faculty Of Pharmaceutical Sciences Nagoya City University

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