An Extensive Survey by the Use of High Performance Liquid Chromatography on Racemization during the Coupling of Benzyloxycarbonyl-L-phenylalanyl-L-valine with L-Proline tert-Butyl Ester

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概要

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• The extent of racemization and the coupling efficiency during the coupling of benzyloxycarbonyl-L-phenylalanyl-L-valine with L-proline tert-butyl ester were conveniently and rapidly determined by the use of high performance liquid chromatography with high accuracy. An extensive examination of various known coupling methods revealed that the coupling methods using diphenyl phosphorazidate (DPPA) and, especially, diethyl phosphorocyanidate (DEPC) afforded the best results. Reported results using DPPA and DEPC as peptide coupling reagents are also summarized (Table I).

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 浜田 康正

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 塩入 孝之

  名古屋市大・薬

• 宅間 昭治

  Funabori Research Laboratories, Daiichi Pure Chemicals, Ltd.

• 宅間 昭治

  Funabori Research Laboratories Daiichi Pure Chemicals Ltd.

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