Molecular Conformation of Patellamide A, a Cytotoxic Cyclic Peptide from the Ascidian Lissoclinum patella, by X-Ray Crystal Analysis

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概要

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• As part of a series of investigations into the conformational stability of a C_2-symmetric or related cyclic peptide isolated from the ascidian Lissoclinum patella, the molecular conformation of patellamide A, the chemical structure of which deviates slightly for C_2-symmetry, was determined by X-ray crystal analysis. Patellamide A took on a saddle-shaped rectangular form and wrapped around the water and methanol solvents. This conformation which is very similar to that of C_2-symmetric ascidiacyclamide would be proposed as a possible candidate for biologically "active" conformation.

• 社団法人日本薬学会の論文
• 1993-10-15

著者

• 塩入 孝之

  名市大・薬

• 塩入 孝之

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 土井 光暢

  大阪薬大

• 石田 寿昌

  大阪薬大

• 尹 康子

  大阪薬科大学

• 石田 寿昌

  大阪薬科大学

• 土井 充暢

  Osaka University of Pharmaceutical Sciences

• 石田 寿昌

  Department of Physical Chemistry Osaka College of Pharmacy

• 土井 光暢

  Department of Physical Chemistry Osaka College of Pharmacy

• 井上 正敏

  Department of Physical Chemistry Osaka College of Pharmacy

• 塩入 孝之

  名城大院・総合学術

• 塩入 孝之

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 塩入 孝之

  名古屋市大・薬

• 井上 正敏

  大阪薬大

• 尹 康子

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• 濱田 康正

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 石田 寿晶

  大阪薬科大学

• Doi Mitsunobu

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 井上 正敏

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 尹 康子

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 濱田 康正

  Faculty Of Pharmaceutical Sciences Nagoya City University

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