Sequence-Dependent Interaction of Acidic Amino Acid with Guanine Base in Tryptophan-Containing Dipeptides : Spectroscopic Studies
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概要
- 論文の詳細を見る
As a model study to investigate the sequence dependence of a peptide for the interaction with nucleic acid base, four kinds of tryptophan-containing dipeptides [Trp-Glu, Glu-Trp, Trp-Gly and Gly-Trp] were synthesized, and their abilities in forming the complexes with guanine base were examined by fluorescence and proton nuclear magnetic resonance (^1H-NMR) methods. The fluorescence titration of each dipeptide with 7-methylguanosine-5'-phosphate (m^7GMP) indicated that although the stacking interaction dominates the binding in each peptide, the carboxyl side chain of Glu plays an additional role in the binding with the base. The effect of Glu residue and its sequence dependence for the interaction was more clearly demonstrated by the ^1H-NMR titration. Since the association constants determined from the downfield shift of the guanine NH_2 resonance exhibited the same tendency as those from the upfield shift of the guanine N7-methyl protons [Trp-Glu > Trp-Gly >Glu-Trp > Gly-Trp], the close cooperation between the hydrogen bond and stacking interactions was suggested to be important for the tight binding of the peptides to the guanine base. Further, it was suggested that the peptide which contains an aromatic amino acid at the N-terminal side and an acidic one at the C-terminal side has an advantage in forming such a complex.
- 社団法人日本薬学会の論文
- 1991-10-25
著者
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土井 光暢
大阪薬大
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石田 寿昌
大阪薬大
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石田 寿昌
Osaka University of Pharmaceutical Sciences
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土井 充暢
Osaka University of Pharmaceutical Sciences
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井上 正敏
Osaka University of Pharmaceutical Sciences
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Usami Yoshiko
Clinical Research Center Nagoya National Hospital:tokai Area Central Hospital For Aids Treatment And
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Ueda H
Kyoto Pharmaceutical University
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井上 正敏
大阪薬大
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土井 光暢
Osaka University of Pharmaceutical Sciences
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加福 やよい
Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences
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加福 やよい
Osaka University of Pharmaceutical Sciences
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上田 仁司
Osaka University of Pharmaceutical Sciences
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伊与 博美
Osaka University of Pharmaceutical Sciences
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USAMI Yoshihide
Osaka University of Pharmaceutical Sciences
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宇佐美 吉英
大阪薬大
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石田 寿晶
大阪薬科大学
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Doi Mitsunobu
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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Ueda H
Hoshi Univ. Tokyo Jpn
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Ueda H
Department Of Physical Chemistry Hoshi University
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Ueda H
Faculty Of Pharmaceutical Sciences Hoshi University
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Ueda Haruhisa
Faculty Of Pharmaceutical Science Hoshi University
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Ueda Hideo
Fac. Of Pharmaceutical Sciences Josai Univ.
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井上 正敏
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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Ueda H
Fac. Of Pharmaceutical Sciences Josai Univ.
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上田 仁司
Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.
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加福 やよい
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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Usami Yoshihide
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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