67(P-51) ムラサキウニ由来真菌の産生する新規細胞毒性物質の化学構造(ポスター発表の部)
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概要
- 論文の詳細を見る
Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. As part of our ongoing search for new antitumour metabolites produced by microorganisms from marine organisms, anthcolorins A (1)-H (8) have been isolated from a strain of Aspergillus versicolor OUPS-N136 originally separated from the sea urchin Anthocidaris crassispina. The absolute stereostructures for these metabolites have been elucidated by spectroscopic and X-ray analyses. Compounds 1-4, 7 and 8 are tricyclic diterpenes with an oxindole moiety, while 5 and 6 have structures in which the C-ring of 1 and 2 is opened. Among these compounds, 1-4 exhibited significant cytotoxicity against cultured P388 cells.
- 天然有機化合物討論会の論文
- 2000-10-01
著者
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山田 剛司
大阪薬大
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土井 光暢
大阪薬大
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沼田 敦
大阪薬大
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山田 恭子
大阪薬大
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土井 充暢
Osaka University of Pharmaceutical Sciences
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箕浦 克彦
大阪薬大
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Doi Mitsunobu
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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箕浦 克彦
大阪薬科大学
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