X-Ray Structural Studies of the Interactions between the Components of Protein and Nucleic Acid. II. Crystal Structure of the Adenin-9-ylethylamine : Phenylacetic Acid (1 : 1) Complex

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概要

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• The crystal structure of a 1 : 1 complex of adenin-9-ylethylamine and phenylacetic acid, C_7H_<10>N_6・C_8H_8O_2,has been determined by the X-ray method. The crystal is orthorhombic, space group P2_12_12_1,with unit-cell dimensions of a=7.050 (2), b=11.835 (4) and c=18.711 (7) A. The structure was solved by the direct method and refined by the blockdiagonal least-squares method to give a final R value of 0.037. In this complex, a salt bridge exists between the anionic carboxyl group of phenylacetic acid and the cationic amino group of adenin-9-ylethylamine. No specific interaction between the adenine and benzene rings was observed. The component molecules are held together by a three-dimensional framework of hydrogen bonds around the twofold screw axis to form an infinite helical array in the a direction.

• 公益社団法人日本薬学会の論文
• 1982-12-25

著者

• 土井 光暢

  大阪薬大

• 石田 寿昌

  Osaka University of Pharmaceutical Sciences

• 井上 正敏

  Osaka University of Pharmaceutical Sciences

• 井上 正敏

  大阪薬大

• 土井 光暢

  Osaka University of Pharmaceutical Sciences

• Doi Mitsunobu

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 井上 正敏

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• 奥野 寿一

  Osaka College of Pharmacy

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