Physicochemical Studies of Medicinal Drug Polymorphism. I. Structural Studies of Bromodiethylacetylurea by Thermal and X-Ray Crystal Analyses

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Three crystalline forms of bromodiethylacetylurea (named α, β and γ) were characrerized by thermal analyses. The α→β→γ structural conversion was accompanied with endothermic change : the transition temperature and enthalpy change were 70.7-83.0℃, ΔH=0.71 (5) kcal/mol for the α→β transition and 83.0-96.5℃, ΔH=0.65 (4) kcal/mol for the β→γ transition, respectively. The γ-type crystal emerged only between 90 and 110℃. X-Ray analyses were performed for α- and β-type crystals. They have two molecules in the asymmetric unit (molecules A and B for α-type, molecules C and D for β-type). Conformational differences among these molecules were not significant, although the hydrogen bond networks characteristic of the two crystal types may be significant in relation to the bioavailabilities of this drug.
社団法人日本薬学会の論文
1985-06-25