Conformational Characteristics of Opioid κ-Receptor Agonist : Crystal Structure of (5S, 7S, 8S)-(-)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide (U69,593), and Conformational Comparison with Some κ-Agonists
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概要
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(5S, 7S, 8S)-(-)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide (U69,593) is a potent agonist to opioid κ-receptor. The crystal structure of U69,593 has been analyzed by the X-ray diffraction method. The molecule, as a whole, took an open conformation, and four cyclic rings composing the main skeleton were far apart from each other. The N and O atoms substituted for the cyclohexane ring were all in the equatorial position. The best planes of two 5-membered rings were almost perpendicular to that of the cyclohexane ring, and the N-methylamide linkage was also orthogonal to this ring plane. The conformation of the U69,593 molecule was compared with other κ-agonists.
- 社団法人日本薬学会の論文
- 1990-07-25
著者
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土井 光暢
大阪薬大
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石田 寿昌
大阪薬大
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石田 寿昌
Osaka University of Pharmaceutical Sciences
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土井 充暢
Osaka University of Pharmaceutical Sciences
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井上 正敏
Osaka University of Pharmaceutical Sciences
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井上 正敏
大阪薬大
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土井 光暢
Osaka University of Pharmaceutical Sciences
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石田 寿晶
大阪薬科大学
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Doi Mitsunobu
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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井上 正敏
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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