93 海水魚由来の真菌の産生する細胞毒性物質および新規キナゾリン誘導体の構造(口頭発表の部)

概要

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Fifteen metabolites were isolated from the mycelium and culture filtrate of a strain of Aspergillus fumigatus which existed in the gastrointestinal tract of the saltwater fish Pseudolabrus japonicus. Among them, TR-2, fumitremorgin C and gliotoxin exhibited significant cytotoxicity against the cultured P-388 lymphocytic leukemia cells. Analysis of long range ^1H-^<13>C COSY and other spectral data for the five new metabolites[FQ-A(1),-B(2),-C(3),-D(4)and -E(5)], exhibiting marginal or moderate cytotoxicity, allowed assignment of their structures containing quinazolone and indoline moieties. The absolute stereostructure of 3 was determined on the basis of X-ray crystallographic analysis as well as of the production of L-(+)-alanine by its acidic hydroloysis. The stereochemistry of the other metabolites was established by deriving 1 and 5, from 3 and other chemical behavior.
天然有機化合物討論会の論文
1991-09-07