12 海洋生物由来のPenicillium属真菌の産生する細胞毒性物質(口頭発表の部)
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Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. As part of our ongoing search for new antitumour metabolites produced by microorganisms from marine organisms, penochalasins A (1)-C (3) have been isolated from a Penicillium sp. originally separated from the marine alga Enteromorpha intestinalis. Furthermore, penostatins A (4)-D (7), F (8) and G (9) have been isolated from this fungal strain cultivated in a different medium from that used for production of penochalasins. The stereostructures and conformations of these metabolites have been elucidated by spectroscopic analyses and some chemical transformations. Penochalasins are a novel class of cytochalasans including a pyrrole ring and exist in different conformers arising from rotation of the C-3-C-10 and C-10-C-3' axes in CDCl_3 and pyndine-d_5. Penostatins A (4)-D (7) and G (9), and F (8) are three-cyclic terpenes including dihydropyran and including cyclooctadienone, respectively. Among these compounds, 1-6 and 8 exhibited significant cytotoxicity against cultured P388 cells.
- 天然有機化合物討論会の論文
- 1996-09-02
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