10 海洋生物由来の菌類の産生する抗腫瘍性物質(口頭発表の部)

概要

論文の詳細を見る
A structurally unique and potent cytotoxic macrolide (1), halichomycin, has been isolated from a strain of Streptomyces hygroscopicus which was isolated from the gastrointestinal tract of the marine fish Halichoeres bleekeri. Furthermore, leptosins A (2)-G(8), G_1(9), G_2(10), H(11)-K(14), K_1(15) and K_2(16), belonging to a series of epipolythiodioxopiperazines, have been isolated as cytotoxic metabolites of a strain of Leptosphaeria sp. isolated from the marine alga Sargassum tortile. Their stereo-structures have been elucidated by spectroscopic analyses and some chemical transformations. The X-ray analysis of 14 demonstrated that two conformers are incorporated in a single crystal in a 1:1 ratio. NOE analyses for solution conformation showed 14 and 16 to exist in only one conformer and in a 1:1 mixture of two conformers in CHCl_3 solution, respectively. All the compounds exhibited significant cytotoxicity against cultured P 388 cells. Especially potent cytotoxicities were observed in dimeric epipolythiodioxo-piperazines (2-4, 8-11 and 14-16). Leptosin A (2) and C (4) exhibited significant antitumour activity against Sarcoma 180 ascites.
天然有機化合物討論会の論文
1994-09-20