101(P50) 海藻由来Penicillium属真菌の細胞毒性代謝産物の構造(ポスター発表の部)

概要

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Marine microorganisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. As part of our ongoing search for new antitumor metabolites produced by microorganisms from marine organisms, we have previously isolated penostatins A-D, F and G from a strain of Penicillium sp. originally separated from the marine alga Enteromorpha intestinalis, and their stereostructures have already been reported. Further investigation for metabolites of this fungal strain has now led to the isolation of eight additional new compounds, penostatins H-O, of which the absolute stereostructures have been elucidated by spectroscopic analyses. The interesting fact was found through this experiment that this fungus produces some pairs of the stereoisomers, between which all the asymmetric centers except for one (C-5) have the opposite absolute configurations. It was considered that all the penostatins from this fungus belong to one of two typical stereoisomers (penostatins A and B). All the compounds obtained in this experiment exhibited significant cytotoxicity against cultured P388 cells.
天然有機化合物討論会の論文
1999-09-01