41(P-1) アメフラシ由来真菌の産生する細胞接着阻害物質(ポスター発表の部)

概要

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Based on the fact that some of the bioactive materials isolated marine animals have been produced by bacteria, we have focused our attention on new antitumour materials from microorganisms inhabiting the marine environment. As part of our ongoing seach for new antitumour metabolites produced by microorganisms from marine organisms, peribysins A (1)- I (9) have been isolated from a strain of Periconia byssoides OUPS-N 133 originally separated from sea hare Aplysia kurodai. The relative stereostructures of 1- 9 have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformations. Compounds 1-9 were examined together with haerbimycin A as standard sample in the cell adhesion assay using human-leukaemia HL-60 cells and human-umbilical-vein endothelial cells (HUVEC). As a result, all of these compounds inhibited the adhesion of HL-60 cell to HUVEC more potently than herbimycin A. Among them, 1 and 4 exhibited especially potent inhibitory activities, and their activities were 127 to 380 times as potent as herbimycin A.
2004-10-01