The Biological Actions of Deoxypodophyllotoxin (Anthricin). I. Physiological Activities and Conformational Analysis of Deoxypodophyllotoxin

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概要

• 論文の詳細を見る

• Deoxypodophyllotoxin (I), which was isolated from Anthriscus sylvestris HOFFM., has strong toxic activity towards killifish (Oryzias latipes) (TLm_<48> : 0.058ppm) and shrimp (Altemia salina) (TLm_<48> : 0.15 ppm). Furthermore, I exhibited the phytogrowth-inhibitory activity against two kinds of plant roots. On the other hand, deoxypicropodophyllin (II), a stereoisomer of I, showed none of these activities. From these results it can be assumed that the difference of activity between I and II is due to a difference in their conformations. Through analysis of the proton nuclear magnetic resonance spectra it was clarified that 1) the conformation at the 5a position of I is quasi-equatorial, whereas that of II is quasi-axial, and 2) the B-ring of I takes a half-chair form, whereas that of II takes a half-boat form.

• 社団法人日本薬学会の論文
• 1985-02-25

著者

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 加藤 喜昭

  Osaka University Of Pharmaceutical Sciences

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 石田 寿昌

  Osaka University of Pharmaceutical Sciences

• 野本 享資

  Suntory Institute for Bioorganic Research

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